Biochimie et physiologie : accès libre

Abstrait

Degradation of Membranes occurs on the Surface of Intra-Endosomal and Intra-Lysosomal Membrane Structures

Heike Sandhoff

Cellular layers enter the lysosome compartment by endocytosis, phagocytosis, or autophagy. Inside the lysosomal compartment, film components of complex structure are corrupted into their building squares. These are able to take off the lysosome and can at that point be utilized for the resynthesizes of complex particles or can be assisting corrupted. Constitutive debasement of films happens on the surface of intra-endosome and intra-lysosomal film structures. Numerous fundamentally film proteins are sorted to the inward films of endosomes and lysosome after ubiquitinylation. Within the lysosome, proteins are debased by proteolytic chemicals, the cathepsins. Phospholipids beginning from lipoproteins or cellular films are debased by phospholipases. Water-soluble glycosidases sequentially cleave off the terminal carbohydrate build-ups’ of glycoproteins, glycosaminoglycans, and glycosphingolipids. For glycosphingolipids with brief oligosaccharide chains, the extra nearness of membrane-active lysosomal lipid-binding proteins is required.