Système gastro-intestinal et digestif

Abstrait

Correlation of Disease Activity, IL-6 & CRP Levels and Leukocytes/Lymphocyte Ratio Among Patients with Acute Pancreatitis

Vedat Goral, Nuh Berekatoglu and Nuriye Mete

Introduction and aim: The aim of this trial is to investigate whether the comparison of Ranson, APACHE II and Balthazar scoring systems with inflammatory mediators CRP, leukocytes/lymphocytes ratio and IL-6 are statistically significant.
Material and method: A total of 52 patients were enrolled in this trial. Ranson and APACHE II scores and serum CRP, leukocytes/lymphocytes ratio and interleukin-6 (IL-6) levels were determined in all patients. In all patients with severe AP, abdominal CT was performed in accordance with Balthazar scoring system. Results: According to correlation of AP scoring and inflammatory mediators, statistical significance was found for correlation of APACHE II with CRP and Ranson scores (P<0.001). Correlation of CRP with Ranson score and IL-6 was statistically significant (P<0.001), a significant correlation was determined between Ranson score and IL-6 (P: 0.014). Leukocytes/lypmhocyte ratio was 12.71 (1.95 ± 34.7) in patients with acute pancreatitis (normal ratio: 2.63) (P<0.001). CT examinations of severe AP cases were graded according to Balthazar scoring system; in Ranson, APACHE II scores and CRP, IL-6 values were found to be elevated, in parallel to increase in scores.
Conclusion: According to our data, we suggest using the IL-6, CRP and leukocytes/lymphocytes ratio a simple indicator of severity in patients presenting with acute pancreatitis.