Médecine néonatale et pédiatrique

Abstrait

Congenital Microgastria in a Premature Infant as an Isolated Anomaly: A Case Report

Sellouti M*, Ayad A, Abilkassem R and Agadr A

Thousands of cases of multisystem inflammatory syndrome in children (MIS-C) have already been reported in children; however, it’s rarely reported in new-borns. MIS-C is a post-infectious immune-mediated condition that typically occurs 3–5 weeks after COVID-19 infection. It usually presents with fever and multi-organ involvement, and blood investigations often show increased inflammatory markers weeks several weeks after exposure to SARS-CoV-2. A 25-day-old male neonate was admitted to the neonatal intensive care unit with symptoms of multi-organ dysfunction
affecting the cardiovascular, respiratory, and haematological systems. The patient exhibited positive inflammatory markers, high levels of ferritin and D-dimer, and elevated cardiac enzymes. Blood cultures were negative for any infection. PCR of nasopharyngeal swab material was positive for respiratory pathogens. Serological tests conducted on both the mother and the patient showed negative results for anti-spike SARS-CoV-2 IgM and anti-nucleocapsid SARSCoV-2 IgG. The patient was diagnosed with neonatal multisystem inflammatory syndrome (MIS-N) and successfully
treated with two doses of intravenous immunoglobulin (1 g/kg/dose) and methylprednisolone (2 mg/kg/day for 5 days). MIS-N related to SARS-CoV-2 can present with cardiorespiratory compromise and carry a higher risk of adverse outcomes in neonates.