Journal des maladies infectieuses et de la pathologie

Abstrait

Concentrations of Tetanus and Diphtheria Antibodies in Vaccinated Children

Surendra Khanal

Previous studies have shown immunologic effects of environmental chemicals, and therefore the European Food Safety Authority (EFSA) recently known a requirement for a lot of studies on PFAS immunotoxicity in numerous populations. Within the Arctic, populations area unit exposed to many environmental chemicals through marine diet, thus the objective of this study was therefore to look at the association between Greenlandic children's exposure to major environmental chemicals and their concentrations of contagious disease and tetanus immunogenic antibodies when vaccination. The study includes cross-sectional information from Greenlandic kids aged 7-12 years examined throughout 2012-2015. a complete of 338 kids were eligible for the study, and one hundred seventy five of those had accessible vaccination records. A parent or guardian participated in a very structured interview, and a blood sample from the kid was analysed for specific antibodies against contagious disease and tetanus in addition as perfluoroalkyl substances (PFASs), polychlorinated biphenyls (PCBs) and total mercury. What is more, for a subgroup, blood samples from maternity were accessible and analysed for environmental contaminants. The associations between the environmental exposures and protein concentrations and odds of getting protein concentrations below the protecting level were examined in linear and supplying regression models