Journal des maladies infectieuses et de la thérapie

Abstrait

Clinical Significance of a Combination of Biochemical Indexes and Immunity Indexes for Hepatitis B Disease Prediction

Wenyan Zhang, Chang Liu, Shan Chen and Junzheng Yang*

Introduction: To explore the clinical significance of the detection of biochemical indexes and immune indexes in the prediction of hepatitis B (HBV) disease. Method: 150 patients with HBV disease who were treated in our hospital from 2018 to 2020 were selected and divided into acute HBV group (group A), chronic HBV group (group B) and Cirrhosis group (C group), every group included 50 cases and 50 healthy people were selected as the control group. Peripheral venous blood was collected from subjects from 4 groups, and immune indexes (plasma immunoglobulin G (IgG), plasma immunoglobulin A (IgA), plasma immunoglobulin M (IgM)) of HBV were measured by immune nephelometry, and biochemical indexes (alanine aminotransferase (ALT) and amino acid transaminase (AST)) of HBV were measured by fasting rate method. Results: Compared with the control group, the immune nephelometry results and fasting rate method showed that the expression of immune indexes (IgG, IgA and IgM) and the expression of biochemical indexes (ALT and AST)in group A, B and C patients were increased significantly (P<0.05). Conclusion: The detection of immune indexes and biochemical indexes has important clinical significance in prediction of HBV patients' condition, and detect a combination of biochemical indexes and immune indexes can be used to make a comprehensive judgment to provide a reliable laboratory basis for diagnosis of HBV patients' condition.