Biologie Cellulaire et Moléculaire

Abstrait

Cellular Senescence in Dreary Tonsillitis and Tonsillar Hypertrophy in Children

Cao Shan

Objective: To watch the contrast in cellular senescence designs between repetitive tonsillitis and tonsillar hypertrophy.

Methods and materials: Forty-three patients analyzed with repetitive tonsillitis or tonsillar hypertrophy, based on therapeutic history and indications, experienced tonsillectomy. The examples were collected and inspected utilizing senescence β-galactosidase recoloring for cellular senescence. Macrophages were identified by immunochemistry.

Results: Cellular senescence was found in both repetitive tonsillitis and tonsillar hypertrophy bunches. The comparison of cellular senescence in microcompartments of tonsil tissue (germinal middle, mantle zone, subepithelial and intraepithelial) uncovered a noteworthy increment of senescent cells in germinal centres in tonsillar hypertrophy compared with that in tonsillar hypertrophy. The lion's share of senescent cells in both bunches were CD68-positive.

Conclusions Different cellular senescence designs were found between the two examined paediatric cases.