Journal de bioterrorisme et de biodéfense

Abstrait

Brucella: Molecular Diagnostic Techniques in Response to Bioterrorism Threat

Riccardo De Santis, Andrea Ciammaruconi, Alice Pomponi, Silvia Fillo and Florigio Lista

Brucellosis, a worldwide zoonosis caused by members of the genus Brucella, is responsible of a considerable human morbidity and economic losses. Although the disease is associated with low mortality and has a relative limited medical impact, Brucella spp., particularly B.melitensis and B. abortus, have been also reported as possible biological weapons. A prompt detection and identification of involved biological agents and the following discrimination between natural outbreaks and/or intentional release of micro-organism, represents the crucial point for an effective response. Furthermore, being members of the genus Brucella genetically homogeneous, the development of accurate strain typing methods is essential in order to investigate the source of an epidemic event. The aim of this paper is to provide an overview of the current molecular diagnostic tools developed as response to bioterrorism episodes.