Le neurologue : revue clinique et thérapeutique

Abstrait

Benefits of Endorphins, in the Treatment of Spinal and Psychiatric Disorders

William Strahan

There are several neurological disorders in which processes related to neurogenesis in the adult brain are affected. B. Cell proliferation, neuronal differentiation and neuronal maturation. Due to their well-known antioxidant and anti-inflammatory and pro-survival effects, endorphins may have utility related to the treatment of neurological disorders. It can regulate processes and promote neuronal maturation of neural progenitor cells and newly formed postmitotic neurons. Endorphins therefore exhibit relevant neurogenic properties that may be helpful in neurological disorders associated with adult cranial neurogenesis disorders. For example, the antiaging properties of endorphins appear to be related to their neurogenic properties. Modulation of neurogenesis by endorphins is beneficial not only in stress, anxiety and depression, but also in ischemic brain and stroke, schizophrenia and amyotrophic lateral sclerosis conditions. Endorphins may be an effective neurogenic therapy to slow the progression of Down syndrome-associated neuropathology. There is finally, further research is needed to elucidate the benefits of endorphin treatment in brain disorders associated with impaired glucose and insulin homeostasis.