Rapports de transplantation : accès libre

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Adult T cell Leukemia and Lymphoma Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant Risk Evaluation

Mayo Yoshimi

Disease status at allogeneic hematopoietic cell transplantation (HCT) is an important pretransplant prognostic factor of HCT in adult T cell leukemia/ carcinoma (ATL); still, other prognostic factors, including comorbidities, weren't prophetic in small cohort analyses. Several scoring systems (HCT-specific comorbidity indicator (HCT- CI)/ modified European Group for Blood and Gist Transplantation threat score (mEBMT)) have been espoused to prognosticate HCT issues in other hematologic malice. We retrospectively estimated HCT- CI and mEBMT to prognosticate nonrelapse mortality (NRM) in 824 ATL cases registered in the Japan Society for Hematopoietic Cell Transplantation TRUMP database, from 2008 until 2013. A advanced HCT- CI was associated with lesser NRM when comparing HCT- CI 0 versus HCT- CI 1 to 3 and HCT- CI 0 versus HCT- CI ≥ 4. An advanced mEBMT score wasn't associated with advanced NRM when comparing mEBMT 0 to 3 with 4 to 6. Because ATL cases are aged and accordingly at threat of fresh complications, we developed an optimized prognostic indicator for ATL (ATL- HCT- PI) using known threat factors age, HCT- CI, and patron – philanthropist coitus combination. The ATL- HCT- PI scores effectively prognosticated the 2- time NRM (22.0, 27.7, and44.4, independently). Thus, the recently developed ATL- HCT- PI, in combination with other threat factors, is more useful for prognosticating NRM in HCT for ATL cases.