Journal de pneumologie et de maladies respiratoires

Abstrait

A Five-Year Prospective Study on Respiratory Viruses' Epidemiology and Immediate Side Effects in Lung Transplant Recipients

Zurbano F

The epidemiology of respiratory contagions (RVs) in lung transplant donors (LTRs) and the relationship of RVs to lung function, acute rejection (AR) and opportunistic infections in these cases aren't well known. We performed a prospective cohort study (2009 – 2014) by collecting nasopharyngeal hearties (NPSs) from asymptomatic LTRs during seasonal changes and from LTRs with upper respiratory tract contagious complaint (URTID), lower respiratory tract contagious complaint (LRTID) and AR. NPSs were anatomized by multiplex polymerase chain response. Overall, 1094 NPSs were collected from 98 cases with a23.6 positivity rate and mean follow- up of3.4 times (interquartile range2.5 –4.0 times). roughly half of URTIDs( 47 of 97,48.5) and tracheobronchitis cases( 22 of 56,39.3) were caused by picornavirus, whereas pneumonia was caused substantially by paramyxovirus( four of nine,44.4) and influenza( two of nine,22.2). In LTRs with LRTID, lung function changed significantly at 1 mo (p = 0.03) and 3 mo (p = 0.04). In a nested case – control analysis, AR was associated with RVs( hazard rate( HR)6.54), Pseudomonas aeruginosa was associated with LRTID( HR8.54), and cytomegalovirus( CMV) replication or complaint was associated with URTID( HR2.53) in the former 3 mo. There was no association between RVs and Aspergillusspp. Colonization or infection (HR0.71). In conclusion, we proved a high prevalence of caravan infections in LTRs. LRTID produced significant lung function abnormalities. Associations were observed between AR and RVs, between. Aeruginosa colonization or infection and LRTID, and between CMV replication or complaint and URTID.